Pub. Date : 2015 Oct
PMID : 26564501
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | [miR-29b Reduces Cisplatin Resistance of Gastric Cancer Cell by Targeting PI3K/Akt Pathway]. | Cisplatin | microRNA 29b-1 | Homo sapiens |
| 2 | OBJECTIVE: To investigate the regulatory effect of miR-29b on gastric cells" resistance to cisplatin. | Cisplatin | microRNA 29b-1 | Homo sapiens |
| 3 | METHODS: The expression of miR-29b in gastric cancer cell line treated with cisplatin concentration gradient was detected using quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) and Western blotting. | Cisplatin | microRNA 29b-1 | Homo sapiens |
| 4 | CCK8 was used to measure the cell viability after cisplatin treatment in condition of miR-29b knock-down and overexpression. | Cisplatin | microRNA 29b-1 | Homo sapiens |
| 5 | RESULTS: The expression of miR-29b was significantly upregualted by cisplatin treatment,while its target gene AKT2 was downregulated. | Cisplatin | microRNA 29b-1 | Homo sapiens |
| 6 | The up-regulation of miR-29b enhanced the sensitivity of gastric cancer cells to cisplatin,while the knock-down of miR-29b enhanced the cisplatin resistance. | Cisplatin | microRNA 29b-1 | Homo sapiens |
| 7 | The up-regulation of miR-29b enhanced the sensitivity of gastric cancer cells to cisplatin,while the knock-down of miR-29b enhanced the cisplatin resistance. | Cisplatin | microRNA 29b-1 | Homo sapiens |
| 8 | Rescue experiments demonstrated that the miR-29b might regulate cisplatin resistance of gastric cancer cell by targeting PI3K/Akt pathway. | Cisplatin | microRNA 29b-1 | Homo sapiens |