Title : Inhibition of the Androgen Receptor by Antiandrogens in Spinobulbar Muscle Atrophy.

Pub. Date : 2016 Mar

PMID : 26563449






7 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Spinal-bulbar muscle atrophy (SBMA) or also named Kennedy"s Disease is caused by a polyglutamine expansion (PolyQ) of the coding region of the androgen receptor (AR). polyglutamine androgen receptor Homo sapiens
2 Spinal-bulbar muscle atrophy (SBMA) or also named Kennedy"s Disease is caused by a polyglutamine expansion (PolyQ) of the coding region of the androgen receptor (AR). polyglutamine androgen receptor Homo sapiens
3 Spinal-bulbar muscle atrophy (SBMA) or also named Kennedy"s Disease is caused by a polyglutamine expansion (PolyQ) of the coding region of the androgen receptor (AR). polyglutamine androgen receptor Homo sapiens
4 The PolyQ triggers a misfolding in the AR-PolyQ and leads to protein aggregation in spinal cord motoneurons and muscle cells. polyglutamine androgen receptor Homo sapiens
5 The PolyQ triggers a misfolding in the AR-PolyQ and leads to protein aggregation in spinal cord motoneurons and muscle cells. polyglutamine androgen receptor Homo sapiens
6 SBMA has been modeled in AR-overexpressing and AR-PolyQ-knock-in animals, but precisely how the PolyQ expansion leads to neurodegeneration is unclear. polyglutamine androgen receptor Homo sapiens
7 SBMA has been modeled in AR-overexpressing and AR-PolyQ-knock-in animals, but precisely how the PolyQ expansion leads to neurodegeneration is unclear. polyglutamine androgen receptor Homo sapiens