Pub. Date : 2015 Nov 12
PMID : 26560363
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Regulation of iron homeostasis by the p53-ISCU pathway. | Iron | tumor protein p53 | Homo sapiens |
| 2 | Here, we report that p53 regulates iron metabolism through the transcriptional regulation of ISCU (iron-sulfur cluster assembly enzyme), which encodes a scaffold protein that plays a critical role in Fe-S cluster biogenesis. | Iron | tumor protein p53 | Homo sapiens |
| 3 | Here, we report that p53 regulates iron metabolism through the transcriptional regulation of ISCU (iron-sulfur cluster assembly enzyme), which encodes a scaffold protein that plays a critical role in Fe-S cluster biogenesis. | Iron | tumor protein p53 | Homo sapiens |
| 4 | Here, we report that p53 regulates iron metabolism through the transcriptional regulation of ISCU (iron-sulfur cluster assembly enzyme), which encodes a scaffold protein that plays a critical role in Fe-S cluster biogenesis. | Iron | tumor protein p53 | Homo sapiens |
| 5 | In addition, in response to DNA damage, p53 induced FTH1 and suppressed transferrin receptor, which regulates iron entry into cells. | Iron | tumor protein p53 | Homo sapiens |
| 6 | HCT116 p53(+/+) cells were resistant to iron accumulation, but HCT116 p53(-/-) cells accumulated intracellular iron after DNA damage. | Iron | tumor protein p53 | Homo sapiens |
| 7 | Our finding revealed a novel role of the p53-ISCU pathway in the maintenance of iron homeostasis in hepatocellular carcinogenesis. | Iron | tumor protein p53 | Homo sapiens |