Pub. Date : 2015
PMID : 26557664
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | All-Trans Retinoic Acid Induces Proliferation, Survival, and Migration in A549 Lung Cancer Cells by Activating the ERK Signaling Pathway through a Transcription-Independent Mechanism. | Tretinoin | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | In this study, we demonstrate that treatment with ATRA can activate the ERK signaling pathway by a transcription-independent mechanism through a signaling cascade that involves RARalpha and PI3K, promoting growth, survival, and migration in lung cancer cells. | Tretinoin | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | The inhibition of the ERK signaling pathway restores the beneficial effects of ATRA, reduces proliferation, increases apoptosis, and blocks the cell migration process in lung cancer cells. | Tretinoin | mitogen-activated protein kinase 1 | Homo sapiens |