Title : Conserved interdomain linker promotes phase separation of the multivalent adaptor protein Nck.

Pub. Date : 2015 Nov 24

PMID : 26553976






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The adaptor protein Nck has three SRC-homology 3 (SH3) domains that bind multiple proline-rich segments in the actin regulatory protein neuronal Wiskott-Aldrich syndrome protein (N-WASP) and an SH2 domain that binds to multiple phosphotyrosine sites in the adhesion protein nephrin, leading to phase separation. Proline NCK adaptor protein 1 Homo sapiens