Title : A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation.

Pub. Date : 2016 Jan 1

PMID : 26553871






4 Functional Relationships(s)
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1 Although it has been shown that known Nlrp3 stimuli converge on potassium ion efflux upstream of Nlrp3 activation, the exact molecular mechanism of Nlrp3 activation remains elusive. Potassium NLR family, pyrin domain containing 3 Mus musculus
2 Although it has been shown that known Nlrp3 stimuli converge on potassium ion efflux upstream of Nlrp3 activation, the exact molecular mechanism of Nlrp3 activation remains elusive. Potassium NLR family, pyrin domain containing 3 Mus musculus
3 Although it has been shown that known Nlrp3 stimuli converge on potassium ion efflux upstream of Nlrp3 activation, the exact molecular mechanism of Nlrp3 activation remains elusive. Potassium NLR family, pyrin domain containing 3 Mus musculus
4 We employed a FACS-based screen for Nlrp3-dependent cell death, using the ionophoric compound nigericin as a potassium efflux-inducing stimulus. Potassium NLR family, pyrin domain containing 3 Mus musculus