Title : Aging related ER stress is not responsible for anabolic resistance in mouse skeletal muscle.

Pub. Date : 2015 Dec 25

PMID : 26551463






2 Functional Relationships(s)
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1 ER stress markers in each muscle were quantified, and the anabolic response to leucine was assessed by measuring the phosphorylation state of S6K1 in soleus and EDL using an ex vivo muscle model. Leucine ribosomal protein S6 kinase, polypeptide 1 Mus musculus
2 S6K1 response to leucine was impaired in soleus, but not in EDL, suggesting that anabolic resistance contributes to soleus weight loss in old mice. Leucine ribosomal protein S6 kinase, polypeptide 1 Mus musculus