Title : Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of LPS-induced inflammation and redox imbalance: Evidence from in vitro and in vivo studies.

Pub. Date : 2016 Feb

PMID : 26548719






2 Functional Relationships(s)
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1 In LPS-stimulated macrophages, non-cytotoxic concentrations of CoQ0 (2.5-10 muM) inhibited iNOS/COX-2 protein expressions with subsequent reductions of NO, PGE2, TNF-alpha and IL-1beta secretions. ubiquinone-O interleukin 1 beta Mus musculus
2 Besides, oral administration of CoQ0 (5 mg/kg) suppressed LPS-induced (1 mg/kg) induction of iNOS/COX-2 and TNF-alpha/IL-1beta through tight regulation of NFkappaB/Nrf2 signaling in mice liver and spleen. ubiquinone-O interleukin 1 beta Mus musculus