Title : Interaction of mouse intestinal P-glycoprotein with oral antidiabetic drugs and its inhibitors.

Pub. Date : 2015 Sep

PMID : 26548081






1 Functional Relationships(s)
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1 In the present study, we explored the binding interactions of antidiabetic drugs i.e., sulfonylurea drugs (glimepiride, glipizide, glyburide) and rapid acting insulin secretagogues viz., nateglinide, repaglinide and rosiglitazone; and Pgp inhibitors i.e., Generation I (verapamil and tamoxifen), III (tetradrine and tariquidar), and natural inhibitors (fumagillin and piperine) in mouse Pgp model. Sulfonylurea Compounds insulin Homo sapiens