Title : Activation of the Farnesoid X-receptor in breast cancer cell lines results in cytotoxicity but not increased migration potential.

Pub. Date : 2016 Jan 28

PMID : 26545738






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We show that activation of the nuclear receptor FXR, either by its endogenous ligand CDCA or the synthetic GW4064, leads to cell death in four breast cancer cell lines with distinct phenotypes: MCF-10A (normal), MCF-7 (receptor positive), MDA-MB-231 and MDA-MB-468 (triple negative). GW 4064 nuclear receptor subfamily 1 group H member 4 Homo sapiens