Pub. Date : 2015 Dec 4-11
PMID : 26541454
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The amounts of MGL_1304 and IgE against MGL_1304 are evaluated by the histamine release test using basophils or mast cells sensitized with serum containing IgE against MGL_1304, and enzyme linked sorbent assay (ELISA) using MGL_1304 and anti-MGL_1304 antibodies. | Histamine | immunoglobulin heavy constant epsilon | Homo sapiens |
| 2 | Here, we identified a human monoclonal IgE (ABS-IgE) that binds to the high affinity IgE receptor (FcepsilonRI) and MGL_1304 with high affinity (KD = 1.99 nM) but does not release histamine from basophils and mast cells. | Histamine | immunoglobulin heavy constant epsilon | Homo sapiens |
| 3 | Here, we identified a human monoclonal IgE (ABS-IgE) that binds to the high affinity IgE receptor (FcepsilonRI) and MGL_1304 with high affinity (KD = 1.99 nM) but does not release histamine from basophils and mast cells. | Histamine | immunoglobulin heavy constant epsilon | Homo sapiens |
| 4 | Moreover, ABS-IgE prevented histamine release from mast cells and basophils by neutralizing MGL_1304 not only in a free form in solution, but also on FcepsilonRI expressed on the cell surface without cell activation. | Histamine | immunoglobulin heavy constant epsilon | Homo sapiens |