Title : High Glucose Concentrations Suppress the Proliferation of Human Periodontal Ligament Stem Cells and Their Differentiation Into Osteoblasts.

Pub. Date : 2016 Apr

PMID : 26537370






2 Functional Relationships(s)
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1 RESULTS: High glucose levels inhibited PDLSC proliferation and differentiation into osteoblasts but induced NF-kappaB activation and subsequent interleukin (IL)-6 and IL-8 expression. Glucose interleukin 6 Homo sapiens
2 Treatment with an NF-kappaB inhibitor rescued the defects in cell proliferation and osteoblastic differentiation and inhibited the IL-6 expression caused by the high-glucose environment. Glucose interleukin 6 Homo sapiens