Title : Functional and Modeling Studies of the Transmembrane Region of the TRPM8 Channel.

Pub. Date : 2015 Nov 3

PMID : 26536261






1 Functional Relationships(s)
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1 Inferences of TRPM8 structure have come from mutagenesis experiments coupled to electrophysiology, mainly regarding the fourth transmembrane helix (S4), which constitutes a moderate voltage-sensing domain, and about cold sensor and phosphatidylinositol 4,5-bisphosphate binding sites, which are both located in the C-terminus of TRPM8. Phosphatidylinositol 4,5-Diphosphate transient receptor potential cation channel subfamily M member 8 Homo sapiens