Pub. Date : 2015 Dec
PMID : 26531821
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: The ATP-binding cassette B1 (ABCB1) gene encodes P-glycoprotein, a transport protein, which plays an important role in the bioavailability of digoxin. | Digoxin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | OBJECTIVE: The ATP-binding cassette B1 (ABCB1) gene encodes P-glycoprotein, a transport protein, which plays an important role in the bioavailability of digoxin. | Digoxin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | OBJECTIVE: The ATP-binding cassette B1 (ABCB1) gene encodes P-glycoprotein, a transport protein, which plays an important role in the bioavailability of digoxin. | Digoxin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | We aimed to investigate the interaction between variants within the ABCB1 gene and digoxin on the risk of sudden cardiac death (SCD). | Digoxin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | Interaction between the ABCB1 polymorphisms and digoxin use was significant for C1236T and G2677T in the age-adjusted and sex-adjusted model. | Digoxin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | CONCLUSIONS: In this study, we showed that in digoxin users variant alleles at each of the three loci in the ABCB1 gene were associated with an increased risk of SCD compared with digoxin users with none or one T allele. | Digoxin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 7 | If replicated, the findings imply that the ABCB1 genotype modifies the risk of cardiac digoxin toxicity. | Digoxin | ATP binding cassette subfamily B member 1 | Homo sapiens |