Pub. Date : 2015 Dec 7
PMID : 26528626
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3). | Metformin | solute carrier family 19 member 3 | Homo sapiens |
| 2 | Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3). | Metformin | solute carrier family 19 member 3 | Homo sapiens |
| 3 | In this study, we tested the reverse, i.e., that metformin is a substrate of thiamine transporters (THTR-1, SLC19A2, and THTR-2, SLC19A3). | Metformin | solute carrier family 19 member 3 | Homo sapiens |
| 4 | In this study, we tested the reverse, i.e., that metformin is a substrate of thiamine transporters (THTR-1, SLC19A2, and THTR-2, SLC19A3). | Metformin | solute carrier family 19 member 3 | Homo sapiens |
| 5 | Our study demonstrated that human THTR-2 (hTHTR-2), SLC19A3, which is highly expressed in the small intestine, but not hTHTR-1, transports metformin (Km = 1.15 +- 0.2 mM) and other cationic compounds (MPP(+) and famotidine). | Metformin | solute carrier family 19 member 3 | Homo sapiens |
| 6 | Our study demonstrated that human THTR-2 (hTHTR-2), SLC19A3, which is highly expressed in the small intestine, but not hTHTR-1, transports metformin (Km = 1.15 +- 0.2 mM) and other cationic compounds (MPP(+) and famotidine). | Metformin | solute carrier family 19 member 3 | Homo sapiens |
| 7 | Our study demonstrated that human THTR-2 (hTHTR-2), SLC19A3, which is highly expressed in the small intestine, but not hTHTR-1, transports metformin (Km = 1.15 +- 0.2 mM) and other cationic compounds (MPP(+) and famotidine). | Metformin | solute carrier family 19 member 3 | Homo sapiens |
| 8 | Furthermore, metformin as well as other drugs including phenformin, chloroquine, verapamil, famotidine, and amprolium inhibited hTHTR-2 mediated uptake of both thiamine and metformin. | Metformin | solute carrier family 19 member 3 | Homo sapiens |
| 9 | Furthermore, metformin as well as other drugs including phenformin, chloroquine, verapamil, famotidine, and amprolium inhibited hTHTR-2 mediated uptake of both thiamine and metformin. | Metformin | solute carrier family 19 member 3 | Homo sapiens |
| 10 | Taken together, our data suggest that hTHTR-2 may play a role in the intestinal absorption and tissue distribution of metformin and other organic cations and that the transporter may be a target for drug-drug and drug-nutrient interactions. | Metformin | solute carrier family 19 member 3 | Homo sapiens |