Pub. Date : 2015 Dec 7
PMID : 26528626
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Our study demonstrated that human THTR-2 (hTHTR-2), SLC19A3, which is highly expressed in the small intestine, but not hTHTR-1, transports metformin (Km = 1.15 +- 0.2 mM) and other cationic compounds (MPP(+) and famotidine). | Famotidine | solute carrier family 19 member 3 | Homo sapiens |
| 2 | Our study demonstrated that human THTR-2 (hTHTR-2), SLC19A3, which is highly expressed in the small intestine, but not hTHTR-1, transports metformin (Km = 1.15 +- 0.2 mM) and other cationic compounds (MPP(+) and famotidine). | Famotidine | solute carrier family 19 member 3 | Homo sapiens |
| 3 | Our study demonstrated that human THTR-2 (hTHTR-2), SLC19A3, which is highly expressed in the small intestine, but not hTHTR-1, transports metformin (Km = 1.15 +- 0.2 mM) and other cationic compounds (MPP(+) and famotidine). | Famotidine | solute carrier family 19 member 3 | Homo sapiens |
| 4 | Furthermore, metformin as well as other drugs including phenformin, chloroquine, verapamil, famotidine, and amprolium inhibited hTHTR-2 mediated uptake of both thiamine and metformin. | Famotidine | solute carrier family 19 member 3 | Homo sapiens |