Title : Modulation of expression of 17-Hydroxylase/17,20 lyase (CYP17) and P450 aromatase (CYP19) by inhibition of MEK1 in a human ovarian granulosa-like tumor cell line.

Pub. Date : 2016

PMID : 26526982






1 Functional Relationships(s)
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1 In conclusion, factors such as c-fos may play a crucial role in the down-regulation of CYP17 and up-regulation of CYP19 in granulosa cells, thereby suppressing androstenedione synthesis. Androstenedione cytochrome P450 family 19 subfamily A member 1 Homo sapiens