Title : Caffeine Suppresses Apoptosis of Bladder Cancer RT4 Cells in Response to Ionizing Radiation by Inhibiting Ataxia Telangiectasia Mutated-Chk2-p53 Axis.

Pub. Date : 2015 Nov 5

PMID : 26521794






4 Functional Relationships(s)
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1 Caffeine Suppresses Apoptosis of Bladder Cancer RT4 Cells in Response to Ionizing Radiation by Inhibiting Ataxia Telangiectasia Mutated-Chk2-p53 Axis. Caffeine tumor protein p53 Homo sapiens
2 RT-PCR indicated caffeine also attenuated transactivation of p53 and p53-inducible genes. Caffeine tumor protein p53 Homo sapiens
3 RT-PCR indicated caffeine also attenuated transactivation of p53 and p53-inducible genes. Caffeine tumor protein p53 Homo sapiens
4 CONCLUSION: Caffeine may inhibit IR-related apoptosis of bladder cancer RT4 cells by suppressing activation of the ATM-Chk2-p53-Puma axis. Caffeine tumor protein p53 Homo sapiens