Title : Taurocholate Induces Cyclooxygenase-2 Expression via the Sphingosine 1-phosphate Receptor 2 in a Human Cholangiocarcinoma Cell Line.

Pub. Date : 2015 Dec 25

PMID : 26518876






1 Functional Relationships(s)
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1 Inhibition of S1PR2 activation with chemical antagonist (JTE-013) or down-regulation of S1PR2 expression with gene-specific shRNA not only reduced COX-2 expression, but also inhibited TCA-induced activation of EGFR and the ERK1/2/Akt-NF-kappaB signaling cascade. Taurocholic Acid AKT serine/threonine kinase 1 Homo sapiens