Pub. Date : 2016 Mar
PMID : 26518726
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sirtuins are Unaffected by PARP Inhibitors Containing Planar Nicotinamide Bioisosteres. | Niacinamide | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 2 | With the exception of a few tankyrase inhibitors, all current PARP inhibitors mimic the nicotinamide moiety in NAD(+) and block the nicotinamide binding pocket. | Niacinamide | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 3 | With the exception of a few tankyrase inhibitors, all current PARP inhibitors mimic the nicotinamide moiety in NAD(+) and block the nicotinamide binding pocket. | Niacinamide | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 4 | These findings indicate that PARP inhibitors containing planar nicotinamide mimetics do not bind to sirtuin cofactor sites. | Niacinamide | poly(ADP-ribose) polymerase 1 | Homo sapiens |