Title : Influence of verapamil on the pharmacokinetics of oxcarbazepine and of the enantiomers of its 10-hydroxy metabolite in healthy volunteers.

Pub. Date : 2016 Feb

PMID : 26514967






2 Functional Relationships(s)
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1 PURPOSE: Oxcarbazepine (OXC), a second-generation antiepileptic, and its chiral metabolite 10-hydroxycarbazepine (MHD) are substrates of P-glycoprotein, which can be inhibited by verapamil. Verapamil ATP binding cassette subfamily B member 1 Homo sapiens
2 CONCLUSION: Verapamil increased the AUC values of both MDH enantiomers, which is probably related to the inhibition of intestinal P-glycoprotein. Verapamil ATP binding cassette subfamily B member 1 Homo sapiens