Title : K(+) regulates Ca(2+) to drive inflammasome signaling: dynamic visualization of ion flux in live cells.

Pub. Date : 2015 Oct 29

PMID : 26512962






2 Functional Relationships(s)
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1 This evidence suggests that both potassium efflux and calcium influx are necessary for mitochondrial reactive oxygen generation upstream of NLRP3 inflammasome assembly and pyroptotic cell death. Oxygen NLR family pyrin domain containing 3 Homo sapiens
2 We propose a model wherein potassium efflux is necessary for calcium influx, resulting in mitochondrial reactive oxygen generation to trigger the NLRP3 inflammasome. Oxygen NLR family pyrin domain containing 3 Homo sapiens