Pub. Date : 2015 Oct 29
PMID : 26512962
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | P2X7 purinergic receptor engagement with extracellular ATP induces transmembrane potassium and calcium flux resulting in assembly of the NLRP3 inflammasome in LPS-primed macrophages. | Calcium | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | This evidence suggests that both potassium efflux and calcium influx are necessary for mitochondrial reactive oxygen generation upstream of NLRP3 inflammasome assembly and pyroptotic cell death. | Calcium | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | We propose a model wherein potassium efflux is necessary for calcium influx, resulting in mitochondrial reactive oxygen generation to trigger the NLRP3 inflammasome. | Calcium | NLR family pyrin domain containing 3 | Homo sapiens |