Pub. Date : 2015 Dec 1
PMID : 26508545
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pin1 is a peptidyl prolyl isomerase that specifically catalyzes cis-trans isomerization of phosphorylated Thr/Ser-Pro peptide bonds in substrate proteins and peptides. | Proline | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 | Homo sapiens |
| 2 | We designed and synthesized a novel series of Pin1 inhibitors based on a glutamic acid or aspartic acid scaffold bearing an aromatic moiety to provide a hydrophobic surface and a cyclic aliphatic amine moiety with affinity for the proline-binding site of Pin1. | Proline | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 | Homo sapiens |