Pub. Date : 2015 Dec 4
PMID : 26507655
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mapping the Binding Site of the Inhibitor Tariquidar That Stabilizes the First Transmembrane Domain of P-glycoprotein. | tariquidar | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Identification of the tariquidar-binding site has been the subject of intensive molecular modeling studies because it is the most potent inhibitor and corrector of P-gp. | tariquidar | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Tariquidar is a unique P-gp inhibitor because it locks the pump in a conformation that blocks drug efflux but activates ATPase activity. | tariquidar | ATP binding cassette subfamily B member 1 | Homo sapiens |