Pub. Date : 2015 Dec 4-11
PMID : 26505793
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | GLP-1 secretion is stimulated by 1,10-phenanthroline via colocalized T2R5 signal transduction in human enteroendocrine L cell. | 1,10-phenanthroline | taste 2 receptor member 5 | Homo sapiens |
| 2 | We hypothesized that GLP-1 hormone is secreted through stimulation of a single bitter taste receptor by 1,10-phenanthroline which is known agonist of taste receptor type 2 member 5 (T2R5). | 1,10-phenanthroline | taste 2 receptor member 5 | Homo sapiens |
| 3 | We hypothesized that GLP-1 hormone is secreted through stimulation of a single bitter taste receptor by 1,10-phenanthroline which is known agonist of taste receptor type 2 member 5 (T2R5). | 1,10-phenanthroline | taste 2 receptor member 5 | Homo sapiens |
| 4 | To prove this hypothesis, we used the representatively well-known 1,10-phenanthroline as ligand of single receptor and evaluated the existence of T2R5 by double-labeling immunofluorescence and then 1,10-phenanthroline is able to secrete GLP-1 hormone through stimulation of T2R5 in human enteroendocrine cells. | 1,10-phenanthroline | taste 2 receptor member 5 | Homo sapiens |
| 5 | Consequently, we verify that GLP-1 hormone is colocalized with T2R5 in the human duodenum and ileum tissue and is secreted by 1,10-phenanthroline via T2R5 signal transduction in differentiated human enteroendocrine L cells. | 1,10-phenanthroline | taste 2 receptor member 5 | Homo sapiens |