Title : Synthesis and Preliminary PET Imaging Studies of a FAAH Radiotracer ([¹¹C]MPPO) Based on α-Ketoheterocyclic Scaffold.

Pub. Date : 2016 Jan 20

PMID : 26505525






1 Functional Relationships(s)
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1 We have identified and radiolabeled a reversible FAAH inhibitor, 7-(2-[(11)C]methoxyphenyl)-1-(5-(pyridin-2-yl)oxazol-2-yl)heptan-1-one ([(11)C]MPPO) in 13% radiochemical yield (nondecay corrected) with >99% radiochemical purity and 2 Ci/mumol (74 GBq/mumol) specific activity. GBQ fatty acid amide hydrolase Homo sapiens