Title : Rhein-Huprine Derivatives Reduce Cognitive Impairment, Synaptic Failure and Amyloid Pathology in AβPPswe/PS-1 Mice of Different Ages.

Pub. Date : 2016

PMID : 26502813






1 Functional Relationships(s)
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1 Two novel enantiopure rhein-huprine hybrids ((+)-1 and (-)-1) exhibit potent inhibitory effects against human acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), BACE-1 and both Abeta and tau antiaggregation activity in vitro and reduction on the amyloid precursor protein (APP) processing in vivo. huprine beta-secretase 1 Homo sapiens