Title : Can active components of licorice, glycyrrhizin and glycyrrhetinic acid, lick rheumatoid arthritis?

Pub. Date : 2016 Jan 12

PMID : 26498361






4 Functional Relationships(s)
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1 OBJECTIVES: This review stated the possible application of the active components of licorice, glycyrrhizin (GL) and glycyrrhetinic acid (GA), in rheumatoid arthritis (RA) treatment based on the cyclooxygenase (COX)-2/thromboxane A2 (TxA2) pathway. Glycyrrhetinic Acid mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 OBJECTIVES: This review stated the possible application of the active components of licorice, glycyrrhizin (GL) and glycyrrhetinic acid (GA), in rheumatoid arthritis (RA) treatment based on the cyclooxygenase (COX)-2/thromboxane A2 (TxA2) pathway. Glycyrrhetinic Acid mitochondrially encoded cytochrome c oxidase II Homo sapiens
3 RESULTS: The active components of licorice GL and GA exert the potential anti-inflammatory effects through, at least in part, suppressing COX-2 and its downstream product TxA2. Glycyrrhetinic Acid mitochondrially encoded cytochrome c oxidase II Homo sapiens
4 CONCLUSIONS: The active components of licorice, GL and GA, could not only potentiate the therapeutic effects but also decrease the adverse effects of NSAIDs or DMARDs through suppressing the COX-2/TxA2 pathway during treatment course of RA. Glycyrrhetinic Acid mitochondrially encoded cytochrome c oxidase II Homo sapiens