Title : Contactin‑associated protein‑like 2 expression in SH‑SY5Y cells is upregulated by a FOXP2 mutant with a shortened poly‑glutamine tract.

Pub. Date : 2015 Dec

PMID : 26497390






3 Functional Relationships(s)
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1 In the present study, constructs expressing wild-type and poly-Q reduction mutants of FOXP2 were generated by polymerase chain reaction (PCR) using lentiviral vectors and transfected into the SH-SY5Y neuronal cell line. polyglutamine forkhead box P2 Homo sapiens
2 Using this cell model, the impact of FOXP2 on the expression of contactin-associated protein-like 2 (CNTNAP2) were investigated, and CNTNAP2 mRNA expression levels were observed to be significantly higher in cells expressing poly-Q-reduced FOXP2. polyglutamine forkhead box P2 Homo sapiens
3 Using this cell model, the impact of FOXP2 on the expression of contactin-associated protein-like 2 (CNTNAP2) were investigated, and CNTNAP2 mRNA expression levels were observed to be significantly higher in cells expressing poly-Q-reduced FOXP2. polyglutamine forkhead box P2 Homo sapiens