Title : Dehydroascorbic Acid Promotes Cell Death in Neurons Under Oxidative Stress: a Protective Role for Astrocytes.

Pub. Date : 2016 Nov

PMID : 26497038






3 Functional Relationships(s)
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1 Although astrocytes are essential for the antioxidant defense of neurons under oxidative stress, a condition in which a large amount of ROS is generated that may favor the extracellular oxidation of AA and the subsequent neuronal uptake of DHA via GLUT3, potentially increasing oxidative stress in neurons. Dehydroascorbic Acid solute carrier family 2 (facilitated glucose transporter), member 3 Mus musculus
2 Thus, DHA promotes the death of stressed neuronal cells, which is reversed by incubating the cells with cytochalasin B, an inhibitor of DHA uptake by GLUT1 and GLUT3. Dehydroascorbic Acid solute carrier family 2 (facilitated glucose transporter), member 3 Mus musculus
3 Thus, DHA promotes the death of stressed neuronal cells, which is reversed by incubating the cells with cytochalasin B, an inhibitor of DHA uptake by GLUT1 and GLUT3. Dehydroascorbic Acid solute carrier family 2 (facilitated glucose transporter), member 3 Mus musculus