Title : In silico studies on the role of mutant Y337A to reactivate tabun inhibited mAChE with K048.

Pub. Date : 2015 Dec 5

PMID : 26494532






1 Functional Relationships(s)
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1 However, in the case of tabun-mutant mAChE(Y337A).K048 conjugate, the replacement of aromatic Tyr337 with the aliphatic alanine unit in the choline binding site, however, loses one of the pi-pi interaction between the active pyridinium ring of K048 and the Tyr337. Choline acetylcholinesterase Mus musculus