Pub. Date : 2015
PMID : 26492522
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | FAM3A Protects HT22 Cells Against Hydrogen Peroxide-Induced Oxidative Stress Through Activation of PI3K/Akt but not MEK/ERK Pathway. | Hydrogen Peroxide | thymoma viral proto-oncogene 1 | Mus musculus |
| 2 | In addition, overexpression of FAM3A significantly increased the activation of Akt and ERK in H2O2 injured HT22 cells. | Hydrogen Peroxide | thymoma viral proto-oncogene 1 | Mus musculus |
| 3 | By using Akt and ERK specific inhibitors, we found that inhibition of PI3K/Akt, but not MEK/ERK pathway, partially prevented FAM3A-induced protection against H2O2. | Hydrogen Peroxide | thymoma viral proto-oncogene 1 | Mus musculus |
| 4 | CONCLUSION: These results suggest that FAM3A has protective effects against H2O2-induced oxidative stress by reducing ROS accumulation and apoptosis, and these protective effects are dependent on the activation of PI3K/Akt pathway. | Hydrogen Peroxide | thymoma viral proto-oncogene 1 | Mus musculus |