Title : FGFR3/fibroblast growth factor receptor 3 inhibits autophagy through decreasing the ATG12-ATG5 conjugate, leading to the delay of cartilage development in achondroplasia.

Pub. Date : 2015 Nov 2

PMID : 26491898






1 Functional Relationships(s)
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1 By employing an embryonic bone culture system, we demonstrated that treatment with autophagy inhibitor 3-MA or chloroquine led to cartilage growth retardation, which mimics the effect of activated-FGFR3 signaling on chondrogenesis. 3-methyladenine fibroblast growth factor receptor 3 Homo sapiens