Title : Molecular mechanisms of cisplatin cytotoxicity in acute promyelocytic leukemia cells.

Pub. Date : 2015 Dec 1

PMID : 26486083






1 Functional Relationships(s)
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1 Cisplatin also activated p53 and phosphorylated activator protein (AP-1) component, c-Jun at serine (63, 73) residue simultaneously leading to cell cycle arrest through stimulation of p21 and down regulation of cyclins and cyclin dependent kinases in APL cell lines. Cisplatin H3 histone pseudogene 16 Homo sapiens