Title : Protective effects of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside in the MPTP-induced mouse model of Parkinson's disease: Involvement of reactive oxygen species-mediated JNK, P38 and mitochondrial pathways.

Pub. Date : 2015 Nov 15

PMID : 26477638






1 Functional Relationships(s)
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1 Previous work from our group suggests that 2,3,5,4"-tetrahydroxystilbene-2-O-beta-D-glucoside (TSG), an active component extracted from a traditional Chinese herb, Polygonum multiflorum thunb, can attenuate 1-methyl-4-phenyl pyridium-induced apoptosis in the neuronal cell line PC12, by inhibiting reactive oxygen species generation and modulating c-Jun N-terminal kinases (JNK) activation. 2,3,5,4'-tetrahydroxystilbene 2-O-glucopyranoside mitogen-activated protein kinase 8 Mus musculus