Title : [Molecular mechanism involved in adhesion of monocytes to endothelial cells induced by nicotine and Porphyromonas gingivalis-LPS].

Pub. Date : 2015 Oct 18

PMID : 26474621






2 Functional Relationships(s)
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Protein Name
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1 In HUVECs, the expressions of CCL-8, Vcam-1, VLA4alpha, OX40 and OX40L were significantly up-regulated by nicotine and P.g-LPS combination compared with nicotine alone, P.g-LPS alone and the untreated control. Nicotine vascular cell adhesion molecule 1 Homo sapiens
2 CONCLUSION: P.g-LPS in combination with nicotine could recruit monocytes to endothelial lesion through up-regulation of CCL-8, and promote adhesion of monocytes to endothelial cells through enhancement of Vcam-1/VLA4alpha and OX40/OX40L interactions, which could be involved in the initiation and development of atherosclerosis. Nicotine vascular cell adhesion molecule 1 Homo sapiens