Pub. Date : 2015 Oct 13
PMID : 26463716
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Butyrate inhibits pro-proliferative miR-92a by diminishing c-Myc-induced miR-17-92a cluster transcription in human colon cancer cells. | Butyrates | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 2 | The effects of butyrate, SAHA and valproic acid on protein levels of c-Myc, Drosha and p57 were measured in HCT-116 cells using immunoblotting. | Butyrates | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 3 | Regulation of C13orf25 promoter activity by butyrate was analyzed by luciferase reporter assay using modified pGL3 constructs containing a wild-type or mutated c-Myc binding site. | Butyrates | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 4 | Treating human colon cancer cells with butyrate reduced the levels of pri-miR17-92a, precursor and mature miR-92a, as well as c-Myc. | Butyrates | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 5 | Mutation of the c-Myc binding site diminished butyrate"s inhibitory effects on C13orf25 promoter activity. | Butyrates | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 6 | c-Myc over-expression neutralized butyrate-induced attenuation of pri-miR17-92a. | Butyrates | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 7 | CONCLUSIONS: Our findings identify a novel cellular mechanism whereby butyrate inhibits miR-92a transcription by reducing c-Myc, thus augmenting p57 levels. | Butyrates | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |