Title : Developing structure-activity relationships from an HTS hit for inhibition of the Cks1-Skp2 protein-protein interaction.

Pub. Date : 2015 Nov 15

PMID : 26463131






2 Functional Relationships(s)
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1 The results of the SAR developed highlight the relationship between the sulfonamide and quinoline nitrogen, while also suggesting that an aryl substituent at the 5-position of the quinoline ring contributes to the potency in the interaction assay. quinoline sarcosine dehydrogenase Homo sapiens
2 The results of the SAR developed highlight the relationship between the sulfonamide and quinoline nitrogen, while also suggesting that an aryl substituent at the 5-position of the quinoline ring contributes to the potency in the interaction assay. quinoline sarcosine dehydrogenase Homo sapiens