Title : New Coumarin Derivatives as Potent Selective COX-2 Inhibitors: Synthesis, Anti-Inflammatory, QSAR, and Molecular Modeling Studies.

Pub. Date : 2015 Dec

PMID : 26462142






1 Functional Relationships(s)
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1 All the bioactive compounds showed in vitro high affinity and selectivity toward the COX-2 isoenzyme, compared to the reference celecoxib with IC50 values ranging from 0.31 to 0.78 muM. Celecoxib mitochondrially encoded cytochrome c oxidase II Homo sapiens