Pub. Date : 2015 Nov
PMID : 26460892
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Curcumin induces p53-independent necrosis in H1299 cells via a mitochondria-associated pathway. | Curcumin | tumor protein p53 | Homo sapiens |
| 2 | Curcumin has been shown to have various therapeutic and/or adjuvant therapeutic effects on human cancers, as it inhibits cancer cell proliferation and induces apoptosis through p53-dependent molecular pathways. | Curcumin | tumor protein p53 | Homo sapiens |
| 3 | However, numerous cancer cell types bear a mutant p53 gene, and whether curcumin has any therapeutic effects on p53-deficient/mutant cancer cells has remained elusive. | Curcumin | tumor protein p53 | Homo sapiens |
| 4 | In conclusion, the present study suggested that curcumin-induced necrotic cell death was mediated via a p53-independent molecular pathway, which was associated with Bax and Bak translocation, caspase activation and cytochrome c release. | Curcumin | tumor protein p53 | Homo sapiens |