Title : Selective disruption of dopamine D2-receptors/beta-arrestin2 signaling by mood stabilizers.

Pub. Date : 2015 Jun

PMID : 26459714






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1 This shows that mood stabilizers lamotrigine, lithium and valproate can exert behavioral effects in mice by disrupting the beta-arrestin 2-mediated regulation of Akt/GSK3 signaling by D2 dopamine receptors, thereby suggesting a shared mechanism for mood stabilizer selectivity. Valproic Acid glycogen synthase kinase 3 beta Mus musculus