Pub. Date : 2015 Sep
PMID : 26459480
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | GM1 in concentrations of 100 nM and 10 muM significantly and substantially increased basal activity of protein kinase B (Akt) (the level of phosphorylated Akt form), but had virtually no effect on its expression in PC12 cells. | G(M1) Ganglioside | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 2 | GM1 in concentrations of 100 nM and 10 muM significantly and substantially increased basal activity of protein kinase B (Akt) (the level of phosphorylated Akt form), but had virtually no effect on its expression in PC12 cells. | G(M1) Ganglioside | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 3 | In the presence of PI3K inhibitor LY294002 preventing protein kinase Akt activation, the protective effect of GM1 significantly decreased. | G(M1) Ganglioside | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 4 | These findings suggest that activation of protein kinase Akt by GM1 contributes to improvement of PC12 cell viability by this ganglioside. | G(M1) Ganglioside | AKT serine/threonine kinase 1 | Rattus norvegicus |