Pub. Date : 2015 Nov
PMID : 26458825
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Akt is translocated to the mitochondria during etoposide-induced apoptosis of HeLa cells. | Etoposide | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | During etoposide-induced apoptosis of HeLa cells, Akt enhances the interaction of second mitochondria-derived activator of caspases/direct IAP binding protein with low pI (Smac/DIABLO) and X-linked inhibitor of apoptosis protein by phosphorylating Smac at serine 67, and thus promotes apoptosis. | Etoposide | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | However, the detailed mechanisms underlying Akt regulation in etoposide-mediated apoptosis remain to be determined. | Etoposide | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | The present study investigated whether etoposide triggers the translocation of Akt into the mitochondria. | Etoposide | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | It was found that Akt activity was increased and sustained during apoptosis triggered by etoposide in HeLa cells. | Etoposide | AKT serine/threonine kinase 1 | Homo sapiens |
| 6 | Concomitantly, the depletion of Akt in the nuclear fraction was observed after etoposide treatment from analysis of confocal microscopy. | Etoposide | AKT serine/threonine kinase 1 | Homo sapiens |
| 7 | The results suggest that etoposide-stimulated Akt is translocated into the mitochondria, thereby possibly enhancing its interaction with Smac and promoting apoptosis in HeLa cells. | Etoposide | AKT serine/threonine kinase 1 | Homo sapiens |