Title : A SERS protocol as a potential tool to access 6-mercaptopurine release accelerated by glutathione-S-transferase.

Pub. Date : 2015 Nov 21

PMID : 26455313






4 Functional Relationships(s)
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1 A SERS protocol as a potential tool to access 6-mercaptopurine release accelerated by glutathione-S-transferase. Mercaptopurine glutathione S-transferase kappa 1 Homo sapiens
2 In this work, we have developed a SERS technique to monitor the absorbance behaviour of 6-mercaptopurine (6-MP) and its glutathione-S-transferase (GST)-accelerated glutathione (GSH)-triggered release behaviour on the surface of gold nanoflowers (GNFs), using the GNFs as excellent SERS substrates. Mercaptopurine glutathione S-transferase kappa 1 Homo sapiens
3 In this work, we have developed a SERS technique to monitor the absorbance behaviour of 6-mercaptopurine (6-MP) and its glutathione-S-transferase (GST)-accelerated glutathione (GSH)-triggered release behaviour on the surface of gold nanoflowers (GNFs), using the GNFs as excellent SERS substrates. Mercaptopurine glutathione S-transferase kappa 1 Homo sapiens
4 We speculated that GST catalyzes nucleophilic GSH to competitively bind with the electrophilic substance 6-MP. Mercaptopurine glutathione S-transferase kappa 1 Homo sapiens