Title : Halofuginone promotes satellite cell activation and survival in muscular dystrophies.

Pub. Date : 2016 Jan

PMID : 26454207






3 Functional Relationships(s)
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1 In cultures of myofibers and myoblasts isolated from dysf(-/-) mice, halofuginone reduced Bax and induced Bcl2 expression levels and induced Akt phosphorylation in a time-dependent manner. halofuginone thymoma viral proto-oncogene 1 Mus musculus
2 Addition of an inhibitor of the phosphinositide-3-kinase/Akt pathway reversed the halofuginone-induced cell survival, suggesting this pathway"s involvement in mediating halofuginone"s effects on survival. halofuginone thymoma viral proto-oncogene 1 Mus musculus
3 Addition of an inhibitor of the phosphinositide-3-kinase/Akt pathway reversed the halofuginone-induced cell survival, suggesting this pathway"s involvement in mediating halofuginone"s effects on survival. halofuginone thymoma viral proto-oncogene 1 Mus musculus