Title : L-Carnitine Ameliorates Cancer Cachexia in Mice Partly via the Carnitine Palmitoyltransferase-Associated PPAR-γ Signaling Pathway.

Pub. Date : 2015

PMID : 26452216






2 Functional Relationships(s)
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1 The mRNA and protein expression levels of PPAR-alpha and PPAR-gamma were decreased in the livers of cancer cachectic mice and increased after L-carnitine administration, which attenuated the increased mRNA expression levels of sterol-regulatory element-binding protein-1c (SREBP-1c) and fatty acid synthase (FAS). Carnitine sterol regulatory element binding transcription factor 1 Mus musculus
2 The mRNA and protein expression levels of PPAR-alpha and PPAR-gamma were decreased in the livers of cancer cachectic mice and increased after L-carnitine administration, which attenuated the increased mRNA expression levels of sterol-regulatory element-binding protein-1c (SREBP-1c) and fatty acid synthase (FAS). Carnitine sterol regulatory element binding transcription factor 1 Mus musculus