Pub. Date : 2016 Jan 1
PMID : 26449471
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sestrin2 is a leucine sensor for the mTORC1 pathway. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 2 | Leucine is a proteogenic amino acid that also regulates many aspects of mammalian physiology, in large part by activating the mTOR complex 1 (mTORC1) protein kinase, a master growth controller. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 3 | We find that leucine, but not arginine, disrupts the Sestrin2-GATOR2 interaction by binding to Sestrin2 with a dissociation constant of 20 micromolar, which is the leucine concentration that half-maximally activates mTORC1. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 4 | The leucine-binding capacity of Sestrin2 is required for leucine to activate mTORC1 in cells. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 5 | The leucine-binding capacity of Sestrin2 is required for leucine to activate mTORC1 in cells. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 6 | These results indicate that Sestrin2 is a leucine sensor for the mTORC1 pathway. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |