Title : Induction of ROS-independent DNA damage by curcumin leads to G2/M cell cycle arrest and apoptosis in human papillary thyroid carcinoma BCPAP cells.

Pub. Date : 2016 Jan

PMID : 26442630






2 Functional Relationships(s)
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1 Interestingly, ATM/ATR activation by curcumin induced phosphorylation of Chk2 (Thr68) followed by that of Cdc25C (Ser216) and Cdc2 (Tyr15), and Cyclin B1 accumulation. Curcumin checkpoint kinase 2 Homo sapiens
2 These results collectively show that curcumin treatment induced the DNA damage response via triggering an ATM-activated Chk2-Cdc25C-Cdc2 signaling pathway. Curcumin checkpoint kinase 2 Homo sapiens