Title : Chronic glucocorticoids exposure enhances neurodegeneration in the frontal cortex and hippocampus via NLRP-1 inflammasome activation in male mice.

Pub. Date : 2016 Feb

PMID : 26434621






3 Functional Relationships(s)
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1 Moreover, DEX treatment for 21 and 28 days significantly increased the proteins expression of NLRP-1, Caspase-1, Caspase-5, apoptosis associated speck-like protein (ASC), nuclear factor-kappaB (NF-kappaB), p-NF-kappaB, interleukin-1beta (IL-1beta), IL-18 and IL-6 in the frontal cortex and hippocampus brain tissue. Dexamethasone interleukin 1 beta Mus musculus
2 Moreover, DEX treatment for 21 and 28 days significantly increased the proteins expression of NLRP-1, Caspase-1, Caspase-5, apoptosis associated speck-like protein (ASC), nuclear factor-kappaB (NF-kappaB), p-NF-kappaB, interleukin-1beta (IL-1beta), IL-18 and IL-6 in the frontal cortex and hippocampus brain tissue. Dexamethasone interleukin 1 beta Mus musculus
3 DEX treatment for 28 days also significantly increased the mRNA expression levels of NLRP-1, Caspase-1, ASC and IL-1beta. Dexamethasone interleukin 1 beta Mus musculus